The ThruProt Analyzer: Bringing Proteomics to the Field Using a Sample-to-Answer Electronic Multiplexed Platform

Mehdi Javanmard received a $344,942 NSF grant for the project "The ThruProt Analyzer: Bringing Proteomics to the Field Using a Sample-to-Answer Electronic Multiplexed Platform". This is a 3-year collaborative grant with colleagues from the RU Ocean Sciences Department, and Mehdi is the PI.

The abstract of the award is given below.

"IDBR: TYPE A- The ThruProt Analyzer: Bringing Proteomics to the Field Using a Sample-to-Answer Electronic Multiplexed Platform".

PI: Mehdi Javanmard,

Co-PIs: Paul G. Falkowski and Debashish Bhattacharya (Rutgers Univ. Ocean Sciences Dept.)

An award is made to Rutgers University New Brunswick to develop a battery powered handheld sensitive instrument whose purpose is to detect panels of proteins for field based environmental monitoring. A portable device for protein analysis virtually impacts all fields of biology and also the biomedical sciences. Protein analysis of environmental samples typically requires collecting and storing samples and returning weeks to months later in labs to begin analyzing the data. The proposed instrument will instead allow for point-of-use on the field analysis of biological samples. The result of this research will be an instrument that is handheld and generalizable to the needs of individual biological laboratories. This disruptive tool will be valuable for basic biology, as well as clinical, biotechnological, and agricultural research. This tool will also have greater societal benefits including improving agricultural practices and deeper insights into environmental biology, which is necessary for protecting the environment. This is multidisciplinary work that combines engineering, nanofabrication, chemistry, physics, and biology and provides a great opportunity to educate and train graduate students, undergraduates, and high school students. One of the important educational outcomes of the proposed research includes building teaching modules that will be incorporated into a massive open online course (MOOC) in biosensor and bioinstrumentation development. For our outreach efforts, we will collaborate with the Rutgers Office for Diversity and Academic Success in the Sciences to attract under-represented students to the study of STEM disciplines.